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Furthermore, they are generally well tolerated, with no hepatotoxicity in patients without liver disease.76 Unfortunately there is no experience in chronic administration in patients with chronic liver disease, particularly those with severe dysfunction

Marcilly MC, Balme B, Haftek M, Wolf F, Grezard P, Berard F, et al

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Moreover, we compared which GLP-1 analogs in clinical phase or launched to confirm if MC4R KO mice is to be a good clinically relevant model to evaluate agents for people with obesity